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Familial Colon Cancer


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About colon cancer?

One of my friends had colon cancer at the age of 23. The doctors are saying that, it's FAP (Familial adenomatous polyposis). The doctors removed the cancer in the first operation. However, she might have to go through another operation of complete seperation of the large colon. In between that, she will go through chemotheraphy. I know that colon cancer is pretty normal after the age of 40. But, what are the complications of such early colon cancer (at the age of 23)? Will she survive? FYI, in cancer level (1,2,3A,3B,4) (1=early stage), her cancer level is 2. In the blood, the infection level is 2 out of 0,1,2,3 (0=no infection). Please mention your filed of expertise.


My sister is 52 and currently in chemo for this condition. She has already lost most of her colon, is on an ileostomy and is hoping for reconnection of her intestines in 4 months. She is at stage 3. There is nothing normal about going through this. Yes, we have the genetic predisposition but she ignored the symptoms for 2 years prior to seeking treatment. There is every reason to believe that survival is the prognosis. Inconvenience and time were her excuses. Now, she knows a colonoscopy and simple test would have taken less time and been less inconvenient.

Updates on Familial Colon Cancer: Diagnosis and Care


Linda M. Farkas, MD, of Duke's Division of Surgical Oncology discusses hereditary colorectal cancer risks and treatments.

My father had colon cancer?

I was reading that parents who get colon cancer may pass it down to their children in the form of "familial adenomatous polyps" or "FAP"
I'm a little concerned I may have this, when I wiped my backside after going to the toilet yesterday I noticed a little blood on the toilet paper.
There was no sensation of pain, burning or constipation.

If my father had colon cancer later in his life, but his father didn't die from it, do you think it is hereditary and will eventually cause me to get cancer? I don't know of any other guys in my family who have it.


Get yourself checked.

My father had colon cancer. A few years ago my wife was in the hospital ( for colon cancer) and she mentioned to her surgeon that my father had colon cancer. Her surgeon insisted I get a colonoscope. Finally, I relented. The surgeon removed 7 polyps, of which 4 were pre cancerous.

My daughter's dr, recommended that she, with a mother and paternal grandfather who had colon cancer,and a father with pre-cancerous polyps, get a colonoscope, and she isn't even 40.

Bottom .line, don't screw around with it.

PANCREAS CANCER! Please read now......................!?

For the past 2 months my Grandma in the Philippines is suffering from
Pancreas Cancer and I am very sad that she is in stage 4. It has been two years since we last hugged each other I am just wondering, what is the cause of her disease? I look at wiki but I don't know which one:

Age (particularly over 60)[2]
Male gender
African-American ethnicity[2]
Smoking. Cigarette smoking nearly doubles one's risk, and the risk persists for at least a decade after quitting. [5]
Diets low in vegetables and fruits[citation needed]
Diets high in red meat[6]
Obesity[7]
Diabetes mellitus
Chronic pancreatitis has been linked, but is not known to be causal
Helicobacter pylori infection
Family history, 5-10% of pancreatic cancer patients have a family history of pancreatic cancer. The genes responsible for most of this clustering in families have yet to be identified. Pancreatic cancer has been associated with the following syndromes; autosomal recessive ataxia-telangiectasia and autosomal dominantly inherited mutations in the BRCA2 gene, Peutz-Jeghers syndrome due to mutations in the STK11 tumor suppressor gene, hereditary non-polyposis colon cancer (Lynch syndrome), familial adenomatous polyposis, and the familial atypical multiple mole melanoma-pancreatic cancer syndrome (FAMMM-PC) due to mutations in the CDKN2A tumor suppressor gene.[8][1]
Gingivitis or periodontal disease.[9]
Alcohol might be a risk factor – see Pancreatic cancer section in Alcohol and cancer

When I lived with her for a decade, she did not qualify to all the things that I listed above EXCEPT she is 74 years old OR maybe she ate dirty foods. Please pray for my grandma because she has 3 months to live.


It is not possible to determine the exact cause for most cancers. The risk factors that you have listed are correlations, not causes. What this means is that we know the risk factor and the disease are linked, but not that one causes another. When we figure out the specific mechanism that causes a cancer, we are well on the way to finding a cure. We are just not there yet with most cancers.


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  • Survival After Colorectal Cancer Diagnosis Is Associated with ...

    Abstract

    Background: Colorectal cancer (CRC) family history is a known risk factor for CRC development; however, effects of CRC family history on survival after CRC diagnosis are less well-defined. Our population-based analysis investigates whether familial CRC cases exhibit improved survival compared with sporadic CRC cases.

    Methods: Cases enrolled in the University of California Irvine Gene-Environment Study of Familial Colorectal Cancer from 1994 to 1996 were analyzed, with follow-up through December 2006. Cases were categorized as familial or sporadic based on self-reported CRC family history in a first-degree relative. Univariate and multivariate survival analyses with Cox proportional hazards ratios were done for overall survival (OS) and CRC-SS (CRC-SS).

    ...

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